Around 11:45 p.m., emergency crews responded to the intersection of Wellington Street and University Avenue for reports of a multi-vehicle collision with pedestrians.
Police said a 26-year-old man was operating a 2014 Jeep Grand Cherokee westbound on Wellington West Avenue, a 53-year-old man was operating a 2022 Honda CRV northbound on University Avenue and a 49-year-old man was operating a 2020 Toyota Corolla northbound on University Avenue .
The 26-year-old man allegedly ran a red light through the intersection and collided with the Honda and Toyota, police said.
Two pedestrians were also hit during the collision.
A 26-year-old male pedestrian was fatally injured and pronounced dead at the scene, police said.
A 32-year-old male pedestrian was seriously injured and taken to hospital.
The occupants of the Honda and Toyota were also taken to the hospital with minor injuries.
Toronto paramedics said they took a total of seven people to hospital.
Nitan Thakur, 26, of Toronto was arrested in connection with the incident and faces six charges, including impaired operation causing death and bodily harm, over 80 operating causing death and bodily harm and dangerous driving causing death and bodily harm damage.
Thakur was scheduled to appear in court on Saturday.  The charges have not been proven.
Police are asking anyone with information or security information or dash cam video to contact investigators at 416-808-1900 or Crime Stoppers anonymously at 416-222-TIPS (8477).